I’m applying to a specialty that offers the option of submitting preference signals to programs.  Can a program I interview with ask me about the programs I might have signaled?

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No.  Programs are prohibited from asking applicants any information about the programs to which they have or may apply, and that includes whether the applicant submitted preferences signals. Program directors who ask for that information could be in violation of the Match Participation Agreement and the matter should be reported to the NRMP.